An exosome product is only as good as its coldest and warmest moment between our freezer and your treatment room. This is what happens in between.
Why temperature matters
Exosomes are membrane structures. Heat, repeated freezing and thawing, and time all degrade them, and once the membrane fails the cargo leaks and the vesicle no longer does anything useful. A vial that read 50 billion particles per millilitre at manufacture can still read 50 billion after a week on a hot loading dock, because the counting instrument does not know the difference between an intact vesicle and a fragment of one. Particle count does not tell you whether a product survived shipping. Handling does.
Where we ship from
Everything ships from our facility in California, where it is manufactured, tested and stored. Orders placed before noon Pacific on Monday to Wednesday leave the same day. We do not ship on Thursday or Friday for liquid products, so nothing sits in a depot over a weekend. Delivery is one to two days to the West Coast and two days to most of the rest of the United States. We currently ship to all 50 states; international orders are handled case by case because of import rules on human-derived material.
How we pack
- Freeze-dried products ship in insulated packaging with gel packs. They tolerate several days at room temperature, so a delayed delivery does not compromise them.
- Liquid products ship in a validated insulated shipper with frozen gel packs, sized for 72 hours below 8 °C. Every box carries a single-use temperature indicator that changes colour if the threshold was exceeded.
- Each shipment includes the certificate of analysis for the lot and a one-page storage guide.
When the box arrives
- Check the temperature indicator before you sign, if the carrier allows. If it has tripped, photograph it and contact us the same day; we replace the shipment.
- Move liquid products to a refrigerator at 2–8 °C immediately. Freeze-dried products go in the refrigerator too, though they are not harmed by a short delay.
- Record the lot number in your product log. You will want it for traceability and for any patient questions.
- Do not freeze liquid products unless the label says so, and never refreeze.
In the treatment room
Reconstitute freeze-dried vials with the supplied diluent immediately before use and use within the time on the label. Bring liquid vials to room temperature for a few minutes before application; do not warm them. Anything left in an opened vial at the end of the day is discarded. Clinics that follow these steps see consistent results from lot to lot, which is the whole point of buying a characterised product.